性 别

男

学历学位

研究生学历、农学博士学位

职 称

副教授

导师类别

博士生导师

专业领域

水产动物营养与饲料

研究方向

水产动物营养与代谢调控；功能性饲料添加剂研发；新型饲料资源开发；

教育与工作经历

2004年9月-2008年6月，河南工业大学，动物科学专业攻读本科

2008年9月-2013年6月，南京农业大学，南京农业大学动物营养与饲料科学专业攻读博士

2013年9月至今，在南京农业大学动物科技学院任教

2018年12月至2019年12月，美国普渡大学农学院访问学者

联系方式

xfli@njau.edu.cn；025-84395382

奖励及荣誉

1、2020年，南京农业大学动物科技学院青年教师授课比赛一等奖；

2、2019年，南京农业大学“钟山学者计划”学术新秀；

3、2018年，南京农业大学动物科技学院青年教师授课比赛三等奖；

4、2018年，中国水产科学研究院科技进步奖一等奖，获奖成果名称：团头鲂养殖全过程营养需要和健康高效饲料研发与示范推广，排名第八；

5、2017年，南京农业大学动物科技学院“丰泽农牧奖教金”；

6、2017年，神农中华农业科技奖三等奖，获奖项目名称：异育银鲫绿色功能性饲料研发与推广，排名第八；

7、2016年，第四届江苏省海洋与渔业科技创新奖一等奖，获奖项目名称：绿色水产营养调控技术体系构建及其在淡水鱼虾中的应用，排名第十。

参加学术团体及任职情况

担任EBioMedicine、Science  of the Total Environment、British Journal of  Nutrition、Life Sciences、Aquaculture、Genome、Reviews  in Aquaculture、Amino Acids、Fish  & Shellfish Immunology、Comparative  Biochemistry and Physiology、Frontiers in  Physiology、Aquaculture Nutrition、Journal  of the Science of Food and Agriculture、Fish Physiology and  Biochemistry、Journal of Thermal Biology、Aquaculture  Research、Journal of Animal Physiology and  Animal Nutrition、Journal of the World Aquaculture  Society、水产学报、中国水产科学等期刊审稿人。

承担科研项目

1、国家自然科学基金面上项目--“转录辅激活因子PGC1β介导的高糖诱导团头鲂线粒体功能损伤机制研究”，项目编号：31872576，起止时间：2019-01-01至2020-12-31；

2、国家自然科学基金青年基金项目--“RNA结合蛋白QKI调控团头鲂糖异生作用的分子机制研究”，项目编号：  31602173，起止时间：2017-01-01至2019-12-31；  

3、中央高校基本科研业务费专项资金项目--“RNA结合蛋白QKI介导的团头鲂胰岛素敏感性调控机制研究”，项目编号：KYZ201645，起止时间：2017-01-01至2019-12-31；

4、中央高校基本科研业务费专项资金项目--“RNA结合蛋白QKI调控团头鲂糖异生作用的分子机制研究”，项目编号：  KJQN201708，起止时间：2017-01-01至2019-12-31；

5、江苏省自然科学基金青年基金项目“高糖胁迫下团头鲂AMPK通路磷酸化水平分析及二甲双胍对其的调控研究”，项目编号：BK20140683，起止时间：2014-07-01至2017-06-30。

论文论著：

一、论文

1. Chao  Xu, Yuan-You Li, Paul B. Brown, Wen-Bin Liu, Liu-Ling Gao, Zhi-Rong Ding, Xiang-Fei  Li*, Di-Zhi Xie*. Interactions between dietary carbohydrate and thiamine:  Implications on the growth performance and intestinal mitochondrial  biogenesis and function of Megalobrama amblycephala [J]. British  Journal of Nutrition, DOI: 10.1017/S000711452100101X.

2. He  Chao-Fan, Liu Wen-Bin, Shi Hua-Juan, Zhang Li, Zhang Ling, Li Xiang-Fei*.  Utilization of pelleted and extruded feed by blunt snout bream Megalobrama  amblycephala: Insights from growth performance, health status and feed  cost [J]. Journal of Animal Physiology and Animal Nutrition, Online, DOI:  10.1111/jpn.13538.

3. Xu  Chao, Liu Wen-Bin, Shi Hua-Juan, Mi Hai-Feng, Li Xiang-Fei^*.  Benfotiamine ameliorates high carbohydrate diet-induced hepatic oxidative  stress, inflammation and apoptosis in Megalobrama amblycephala [J].  Aquaculture Research, Online, DOI: 10.1111/are.15164.

4. Zhang Ling, Zheng Xiao-Chuan, Huang Yang-Yang, Ge Ya-Ping, Sun  Miao,  Chen Wei-Liang, Liu Wen-Bin, Li Xiang-Fei*. Carbonyl cyanide  3-chlorophenylhydrazone induced the imbalance of mitochondrial homeostasis in  the liver of Megalobrama amblycephala: A dynamic study [J]. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2021, 244: 109003.

5. 徐超，刘文斌，李远友，谢帝芝，丁志荣，李向飞^*. 苯磷硫胺对饲喂高糖饲料团头鲂血浆生化指标及肝脏糖脂代谢的影响[J]. 中国水产科学，2021，28(2): 186-194.

6. 徐超，李远友，刘文斌，谢帝芝，丁志荣，Jean-Jacques  Yao Adjoumani，石泉，李向飞^*. 团头鲂PGC1β基因克隆及高糖胁迫、葡萄糖和胰岛素负荷对其mRNA表达的影响[J]. 中国水产科学，2021，接收。

7. 孙淼，何超凡，张玲，刘文斌，蒋广震，李向飞^*. 不同水温与饲料磷水平对日本沼虾生产性能、组织及水体磷含量的影响[J]. 水产学报，2021，接收。

8. Zhang  Li, Liu Wen-Bin, Paul B. Brown, Xu Chao, Shi Hua-Juan, Zheng Xiao-Chuan,  Zhang Ling, Huang Yang-Yang, He Chang, Li Xiang-Fei*. Utilization of  raw and gelatinized starch by blunt snout bream Megalobrama amblycephala  as evidenced by the glycolipid metabolism, glucose tolerance and  mitochondrial function [J]. Aquaculture, 2020, 529: 735603.

9. Shi  Hua-Juan, Liu Wen-Bin, Xu Chao, Zhang Li, Liu Jie, Zhang Ding-Dong, Zhang  Ling, Li Xiang-Fei*. Transcriptional regulation of the AMP-activated  protein kinase and glycolipid metabolism-related genes by insulin and  glucagon in blunt snout bream (Megalobrama amblycephala): a  comparative study [J]. Aquaculture, 2020, 515: 734553.

10. Xu  Chao, Zhong Xiao-Qun, Li Xiang-Fei*,  Shi Hua-Juan, Liu Wen-Bin. Regulation of growth, intestinal microflora  composition and expression of immune-related genes by dietary supplementation  of Streptococcus faecalis in blunt snout bream (Megalobrama  amblycephala) [J]. Fish & Shellfish Immunology, 2020, 105: 195-202.

11. Xu  Chao, Liu Wen-Bin, Wang Bing-Ke, Li  Xiang-Fei*. Restricted feeding benefits the growth performance and  glucose homeostasis of blunt snout bream Megalobrama amblycephala fed  high-carbohydrate diets [J]. Aquaculture Reports, 2020, 18: 100513.

12. Li Xiang-Fei, Wang Bing-Ke,  Xu Chao, Shi Hua-Juan, Zhang Li, Liu Jia-Dai, Tian Hong-Yan, Liu Wen-Bin. Regulation  of mitochondrial biosynthesis and function by dietary carbohydrate levels and  lipid sources in juvenile blunt snout bream Megalobrama amblycephala  [J]. Comparative Biochemistry and Physiology Part A, 2019, 227: 14-24.

13. Abasubong  Kenneth Prudence, Liu Wen-Bin, Adjoumani Yao Jean-Jacques, Xia Si-Lei, Xu  Chao, Li Xiang-Fei*. Xylooligosaccharides benefits the growth,  digestive functions and TOR signaling in Megalobrama amblycephala fed  diets with fish meal replaced by rice protein concentrate  [J]. Aquaculture, 2019, 500: 417-428.

14. Jiang  Guang-Zhen, Shi Hua-Juan, Xu Chao, Zhang Ding-Dong, Liu Wen-Bin, Li  Xiang-Fei*. Glucose-6-phosphate dehydrogenase in blunt snout bream Megalobrama  amblycephala: molecular characterization, tissue distribution and the  responsiveness to dietary carbohydrate levels [J]. Fish Physiology and  Biochemistry, 2019, 45: 401-415.

15. Zhong Xiao-Qun, Liu Ming-Yang, Xu Chao, Liu Wen-Bin, Abasubong  Kenneth Prudence, Li Xiang-Fei*. Dietary  supplementation of Streptococcus faecalis benefits the feed  utilization, antioxidant capability, innate immunity and disease resistance  of blunt snout bream (Megalobrama amblycephala) [J]. Fish  Physiology and Biochemistry, 2019, 45: 643-656.

16. Xu  Chao, Liu Wen-Bin, Rem➢ Sofie Charlotte, Wang Bing-Ke, Shi Hua-Juan, Zhang  Li, Liu Jia-Dai, Li Xiang-Fei*. Feeding restriction alleviates high  carbohydrate diet-induced oxidative stress and inflammation of Megalobrama  amblycephala by activating the AMPK-SIRT1 pathway [J]. Fish &  Shellfish Immunology, 2019, 92: 637-648.

17. Xu  Chao, Liu Wen-Bin, Zhang Ding-Dong, Cao Xiu-Fei, Shi Hua-Juan, Li Xiang-Fei*.  Interactions between dietary carbohydrate and metformin: Implications on energy  sensing, insulin signaling pathway, glycolipid metabolism and glucose  tolerance in blunt snout bream Megalobrama amblycephala [J].  Aquaculture, 2018, 483: 183-195.

18. Cai  Wan-Cun, Jiang Guang-Zhen, Li Xiang-Fei*, Sun Cun-Xin, Mi Hai-Feng,  Liu Shuang-Qing, Liu Wen-Bin*. Effects of complete fish meal  replacement by rice protein concentrate with or without lysine supplement on  growth performance, muscle development and flesh quality of blunt snout bream  (Megalobrama amblycephala) [J]. Aquaculture Nutrition, 2018,  24: 481-491.

19. Shi  Hua-Juan, Liu Wen-Bin, Xu Chao, Zhang Ding-Dong, Wang Bing-Ke, Zhang Li, Li  Xiang-Fei*. Molecular characterization of the RNA-binding protein  quaking-a in Megalobrama amblycephala: response to high-carbohydrate  feeding and glucose/insulin/glucagon treatment [J]. Frontiers in Physiology,  2018, 9: 434. doi: 10.3389/fphys.2018.00434.

20. Abasubong  Kenneth Prudence, Liu Wen-Bin, Zhang Ding-Dong, Yuan Xiang-Yang, Xia Si-Lei,  Xu Chao, Li Xiang-Fei*. Fishmeal replacement by rice protein  concentrate with xylooligosaccharides supplement benefits the growth  performance, antioxidant capability and immune responses against Aeromonas  hydrophila in blunt snout bream (Megalobrama amblycephala)  [J]. Fish & Shellfish Immunology, 2018, 78: 177-186.

21. Cai  Wan-Cun, Liu Wen-Bin, Jiang Guang-Zhen, Wang Kai-Zhou, Sun Cun-Xin, Li  Xiang-Fei. Lysine supplement benefits the growth performance, protein  synthesis and muscle development of Megalobrama amblycephala fed diets  with fish meal replaced by rice protein concentrate [J]. Fish  Physiology and Biochemistry, 2018, 44(4): 1159-1174.

22. Xu  Chao, Liu Wen-Bin, Zhang Ding-Dong, Shi Hua-Juan, Zhang Li, Li  Xiang-Fei*. Benfotiamine, a lipid-soluble analogue of vitamin B₁,  improves the mitochondrial biogenesis and function of blunt snout bream (Megalobrama  amblycephala) fed high-carbohydrate diets by promoting the  AMPK/PGC-1β/NRF-1 axis [J]. Frontiers in Physiology, 2018, 9: 1079. doi:  10.3389/fphys.2018.01079.

23. Shi  Hua-Juan, Xu Chao, Liu Ming-Yang, Wang Bing-Ke, Liu Wen-Bin, Chen Dan-Hong,  Zhang Li, Xu Chen-Yuan, Li Xiang-Fei*. Resveratrol improves the energy  sensing and glycolipid metabolism of blunt snout bream Megalobrama  amblycephala fed high-carbohydrate diets by activating the  AMPK–SIRT1–PGC-1α network [J]. Frontiers in Physiology, 2018, 9: 1258. doi:  10.3389/fphys.2018.01258.

24. Li Xiang-Fei, Xu Chao, Jiang  Guang-Zhen, Zhang Ding-Dong, Liu Wen-Bin. Molecular characterization of  fructose-1,6-bisphosphatase 1b in blunt snout bream Megalobrama  amblycephala and the transcriptional response to glucose loading after  the adaptation to high-carbohydrate diets [J]. Fish  Physiology and Biochemistry, 2017, 43: 1337-1349.

25. Li Xiang-Fei, Wang Tian-Jiao,  Qian Yu, Jiang Guang-Zhen, Zhang Ding-Dong, Liu Wen-Bin. Dietary niacin  requirement of juvenile blunt snout bream Megalobrama amblycephala  based on a dose-response study [J]. Aquaculture Nutrition, 2017, 23:  1410-1417.

26. Xu  Chao, Liu Wen-Bin, Dai Yong-Jun, Jiang Guang-Zhen, Wang Bing-Ke, Li  Xiang-Fei*. Long-term administration of benfotiamine benefits the glucose  homeostasis of juvenile blunt snout bream Megalobrama amblycephala fed  a high-carbohydrate diet [J]. Aquaculture, 2017, 470: 74-83.

27. Xu  Chao, Liu Wen-Bin, Zhang Ding-Dong, Wang Kai-Zhou, Xia Si-Lei, Li  Xiang-Fei*. Molecular characterization of AMP-activated protein kinase α2  from herbivorous fish Megalobrama amblycephala and responsiveness to  glucose loading and dietary carbohydrate levels [J]. Comparative Biochemistry  and Physiology Part A, 2017, 208: 24-34.

28. Wang  Bing-Ke, Liu Wen-Bin, Xu Chao, Cao Xiu-Fei, Zhong Xiao-Qun, Shi Hua-Juan, Li  Xiang-Fei*. Dietary carbohydrate levels and lipid sources modulate the  growth performance, fatty acid profiles and intermediary metabolism of blunt  snout bream Megalobrama amblycephala in an interactive pattern [J].  Aquaculture, 2017, 481: 140-153.

29. Li Xiang-Fei, Xu Chao, Zhang  Ding-Dong, Jiang Guang-Zhen, Liu Wen-Bin. Molecular characterization and  expression analysis of glucokinase from herbivorous fish Megalobrama  amblycephala subjected to a glucose load after the adaption to dietary  carbohydrate levels [J]. Aquaculture, 2016, 459:89-98 (IF=2.57).

30. Li Xiang-Fei, Xu Chao, Tian  Hong-Yan, Jiang Guang-Zhen, Zhang Ding-Dong, Liu Wen-Bin. Feeding rates  affect stress and non-specific immune responses of juvenile  blunt snout bream Megalobrama amblycephala subjected to hypoxia  [J]. Fish & Shellfish Immunology, 2016, 49(2): 298-305.

31. Li Xiang-Fei, Wang Fei, Qian  Yu, Jiang Guang-Zhen, Zhang Ding-Dong, Liu Wen-Bin. Dietary vitamin B₁₂  requirement of fingerling blunt snout bream Megalobrama amblycephala  determined by growth performance, digestive and absorptive capability and  status of the GH-IGF-I axis [J]. Aquaculture, 2016, 464: 647-653.

32. Li Xiang-Fei, Lu Kang-Le, Liu  Wen-Bin, Jiang Guan-Zhen, Xu Wei-Na. Effects of dietary lipid and  carbohydrate and their interaction on growth performance and body composition  of juvenile blunt snout bream, Megalobrama amblycephala [J]. The  Israeli Journal of Aquaculture-Bamidgeh, 2014, IJA_66, 931.

33. Li Xiang-Fei, Tian Hong-Yan,  Zhang Ding-Dong, Jiang Guang-Zhen, Liu Wen-Bin. Feeding frequency affects  stress, innate immunity and disease resistance of juvenile blunt snout bream Megalobrama  amblycephala [J]. Fish & Shellfish Immunology, 2014, 38(1): 80-87.

34. Li Xiang-Fei, Wang Ying, Liu  Wen-Bin, Jiang Guang-Zhen, Zhu Jie. Effects of dietary carbohydrate/lipid  ratios on growth performance, body composition and glucose metabolism of  fingerling blunt snout bream Megalobrama amblycephala [J]. Aquaculture  Nutrition, 2013, 19(5): 701-708.

35. Li Xiang-Fei, Jiang  Guan-Zhen, Qian Yu, Xu Wei-Na, Liu Wen-Bin. Molecular characterization of  lipoprotein lipase from blunt snout bream Megalobrama  amblycephala and the regulation of its activities and expression  by dietary lipid levels [J]. Aquaculture, 2013, 416-417: 23-32.

36. Li Xiang-Fei, Jiang  Yang-Yang, Liu Wen-Bin, Ge Xian-Ping. Protein-sparing effect of dietary lipid  in practical diets for blunt snout bream (Megalobrama amblycephala)  fingerlings: effects on digestive and metabolic responses [J]. Fish  Physiology and Biochemistry, 2012, 38(2): 529-541.

37. Li Xiang-Fei, Liu Wen-Bin, Lu  Kang-Le, Xu Wei-Na, Wang Ying. Dietary carbohydrate/lipid ratios affect  stress, oxidative status and non-specific immune responses of fingerling  blunt snout bream, Megalobrama amblycephala [J]. Fish & Shellfish  Immunology, 2012, 33(2): 316-323.

38.      Li  Xiang-Fei, Liu Wen-Bin, Jiang Yang-Yang, Zhu Hao, Ge  Xian-Ping. Effects of dietary protein and lipid levels in practical diets on  growth performance and body composition of blunt snout bream (Megalobrama  amblycephala) fingerlings [J]. Aquaculture, 2010, 303(1): 65-70.

二、专利

1. 李向飞，刘文斌，徐超，蒋广震，张定东. 一种改善鱼体糖耐受性的调控组合物及其制备方法与应用[P]. 中国专利，2019年2月，专利号：ZL201510811938.6;

2. 李向飞，刘文斌，王冰柯，蒋广震，张定东. 一种渔用糖代谢调控物及其制备方法与应用[P]. 中国专利，2018年9月，专利号：ZL201610261110.2;

3. 李向飞，徐超，刘文斌，张定东，蒋广震. 一种高效水产糖代谢调控组合物及其制备方法与应用[P]. 中国专利，2018年11月，申请号：201811316474.1;

4. 刘文斌，李向飞，徐维娜，蒋广震. 一种蛋白节约型团头鲂幼鱼配合饲料及其制备方法[P]. 中国专利，2013年10月，专利号：ZL201210558716.4。